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The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes

Phillips, L. K.; Peake, J. M.; Zhang, X.; Hickman, I. J.; Kolade, O.; Sacre, J. W.; Huang, B. E.; Simpson, P.; Li, S. H.; Whitehead, J. P.; Sharman, J. E.; Martin, J. H.; Prins, J. B.

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2010-09

10.1210/jc.2010-0413

PMID: 20610595

Abstract:

CONCLUSIONS: Obesity is associated with an attenuated overall postprandial decrease in AIx. Subjects with T2DM have a preserved, but significantly prolonged, reduction in AIx after a high-fat meal. The correlation between AIx and triglycerides suggests that postprandial dysmetabolism may impact on vascular dynamics. The markedly different response observed in the obese subjects compared with those with T2DM was unexpected and warrants additional evaluation.