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A Plant-Based Dietary Intervention Improves Beta-Cell Function and Insulin Resistance in Overweight Adults: A 16-Week Randomized Clinical Trial
Kahleova, Hana; Tura, Andrea; Hill, Martin; Holubkov, Richard; Barnard, Neal D.
Abstract:
The aim of this study was to test the effect of a plant-based dietary intervention on beta-cell function in overweight adults with no history of diabetes. Participants (n = 75) were randomized to follow a low-fat plant-based diet (n = 38) or to make no diet changes (n = 37) for 16 weeks. At baseline and 16 weeks, beta-cell function was quantified with a mathematical model. Using a standard meal test, insulin secretory rate was calculated by C-peptide deconvolution. The Homeostasis Model Assessment (HOMA-IR) index was used to assess insulin resistance while fasting. A marked increase in meal-stimulated insulin secretion was observed in the intervention group compared with controls (interaction between group and time, Gxt, p < 0.001). HOMA-IR index fell significantly (p
Automatic Tags
Female; Humans; Male; Adult; Obesity; Adiposity; Aged; Middle Aged; diabetes; Weight Loss; Diet, Fat-Restricted; Body Mass Index; Energy Intake; Insulin Secretion; Insulin Resistance; Diet, Reducing; Diet, Vegan; Insulin; nutrition; vegan; Absorptiometry, Photon; Overweight; Postprandial Period; Intra-Abdominal Fat; Insulin-Secreting Cells; beta-cell function; District of Columbia
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