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Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial

Jebb, Susan A.; Lovegrove, Julie A.; Griffin, Bruce A.; Frost, Gary S.; Moore, Carmel S.; Chatfield, Mark D.; Bluck, Les J.; Williams, Christine M.; Sanders, Thomas Ab; Group, RISCK Study

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2010-10

10.3945/ajcn.2009.29096

PMID: 20739418

Abstract:

CONCLUSIONS: This study did not support the hypothesis that isoenergetic replacement of SFAs with MUFAs or carbohydrates has a favorable effect on Si. Lowering GI enhanced reductions in TC and LDL-cholesterol concentrations in subjects, with tentative evidence of improvements in Si in the LF-treatment group. This trial was registered at clinicaltrials.gov as ISRCTN29111298.