Recent History
May 12, 1851
Jean-Francois Dancel
Obesity, Carnivore, Keto
Obesity, or, Excessive corpulence : the various causes and the rational means of cure
Madame d'Aries of Spain used the carnivore diet for obesity. "Following your directions, I have lost weight. Since my last two confinements the abdomen had remained unduly large: it is now much smaller. I feel lighter."
Madame d'Aries, a resident of Bilbao, in Spain, wife of the French Consul wrote to me on the 12th of May last:—"Following your directions, I have lost weight. Since my last two confinements the abdomen had remained unduly large: it is now much smaller. I feel lighter. I have always been able to walk without experiencing much fatigue. It was a great trouble, however, to move from my seat. A peculiar inward feeling, which was a source of great annoyance, has become almost imperceptible. I can go up stairs without bringing on shortness of breath, and the benefit derived is as evident to myself as it is visible to others."
June 5, 1851
Jean-Francois Dancel
Obesity, Carnivore, Keto
Obesity, or, Excessive corpulence : the various causes and the rational means of cure
Dancel returns a young woman to health with meat, and her menstruation returns as well. "This young person, about twenty-three years of age, was very fat, and irregular in her menstrual periods. She was of lymphatic temperament, very pale, and rarely partook of meat: her ordinary food consisted of vegetables, sweetmeats, cakes and sweet fruits; She had lost much of her fat, and had become regular. She ate meat principally, both at breakfast and dinner, and drank wine."
To return to the cases of cure. Madam C., a landed proprietor, living in the Rue de la Concorde, at Paris, went to take the waters in Germany, in the year 1851. On her return, she made trial of my system, on account of excessive corpulence. Meeting with the usual success, she thought it would be of great advantage to a young lady, a friend, whom she had left behind her at the watering place, and who was then in bad health. This young person, about twenty-three years of age, was very fat, and irregular in her menstrual periods. She was of lymphatic temperament, very pale, and rarely partook of meat: her ordinary food consisted of vegetables, sweetmeats, cakes and sweet fruits; water was her principal beverage. At the pressing instance of Madam C., Miss C. visited Paris, in order to be under my care.
After following my directions for a fortnight, her health was much improved. Her parents then came to Paris, and I continued in attendance on Miss C. for three months. At the expiration of this time, she returned with her parents to Brussels. She had lost much of her fat, and had become regular. She ate meat principally, both at breakfast and dinner, and drank wine. I may lay claim, in the case of this young lady, to have effected a complete change of temperament. With but trifling menstrual flow, and great pallor, she was gradually progressing to a state of obesity, which would have proved entirely destructive to health, which would have ended in a total suppression of the menses, and ultimately in death. But now, having overcome her obesity, the menstrual flow has become normal in quantity, the digestive powers have resumed their functional activity, so that she can partake of meat and wine, and in every respect her constitution is fully restored. Should she marry, she will in all probability have a family, which would have been very doubtful had she married while in the previous obese condition; and if she have children, her accouchements will be comparatively free of danger, and her sufferings much less; for it is well known that very corpulent females have more difficult labours than those of ordinary embonpoint; while the offspring of the latter are at the same time healthier. The same rule applies in the case of the human female as with other mammalia; when fat, conception is of more rare occurrence; and when they do conceive, they are very liable to miscarry. When, however, they go to the full period of gestation, the progeny of a very fat mother is almost always lean, and possesses little vitality. Moreover, the milk of a very fat mother is neither so abundant nor so nutritious as that of a moderately thin mother.
August 21, 1851
Jean-Francois Dancel
Obesity, Carnivore, Keto
Obesity, or, Excessive corpulence : the various causes and the rational means of cure
Madame Meuriot uses the carnivore diet to cure her obesity and swollen legs and then becomes pregnant. Perhaps an early case of PCOS.
Madame Meuriot, an actress, then staying at Chatellerault, addressed me under date the 21st of August, 1851. Her letter is exceedingly lengthy and full of minutiæaelig;, that would be improper to lay before the public. But she informs me that her weight in the course of a single year had increased from one hundred and twenty to one hundred and seventy-five pounds. In order to retain her theatrical engagements, she determined to use every possible means to overcome this troublesome embonpoint. She took her food in quantity barely sufficient to sustain nature; made use of sea biscuit instead of bread that she might eat less. For some time past she has been taking daily forty drops of the tincture of iodine, under the direction of a physician, but without appreciable benefit. Every portion of the body was loaded with fat, and the lower part of the legs were swollen. Having met with my book and dreading the effects of the iodine upon her general health, she was anxious that I should advise her. I did so; and sent the medicine, together with necessary directions from Paris to Perpignau, where she was then staying. I received a letter from her on the 9th of October following, in which she says:—"I am happy to inform you that your treatment has been attended with the most satisfactory results. My legs are no longer swollen. I walk with greater ease than formerly, and my breathing is no longer oppressed. I am unable to say how much my weight has decreased, not having ready access to platform scales; but my gowns tell me that my size is less than it was, yet not as small as could be desired."
In conclusion she wished to know whether she might continue the treatment a month or two longer, and if I thought so, to please send her the requisite medicine. I did so, and heard nothing further from Madame de Meuriot until the month of August in the following year. She was then on her way to fulfil an engagement at Lille, and called to see me. She expressed great delight in having got rid of her troublesome embonpoint, and said that she had not been afflicted with swelling of the legs since placing herself under my treatment. "But something has occurred which I did not in the least expect: since my corpulency has left me, I have become enceinte."
A letter from this lady, dated Lille, the 13th October last, begins thus:—"Since I last had the pleasure of seeing you, on the occasion of my departure from Paris, I have become fully satisfied that I am in the family way, and have been so for the past eight months." My advice was requested on some points having reference to her then condition.
The preceding facts tend to shew that reduced corpulency is favourable to conception.
November 1, 1851
Jean-Francois Dancel
Obesity, Carnivore, Keto
Obesity, or, Excessive corpulence: the various causes and the rational means of cure
Mr. G. Chauvin owing to his increasing corpulency adopted my mode of treatment, and in one of his letters, dated November, 1851, he says: "I have followed your directions, which have effected the result I was led to expect. My family have expressed their astonishment at the sudden and extraordinary diminution of size. But it has been effected without the slightest bad symptom."
Mr. G. Chauvin, a lawyer, living at Castellane, in the department of the Lower Alps, owing to his increasing corpulency, was subject to great inconvenience when speaking in court. He adopted my mode of treatment, and in one of his letters, dated November, 1851, he says: "I have followed your directions, which have effected the result I was led to expect. My family have expressed their astonishment at the sudden and extraordinary diminution of size. But it has been effected without the slightest bad symptom: the bodily functions have been duly discharged, and the treatment has been unattended with inconvenience or danger, &c."
December 15, 1851
Jean-Francois Dancel
Obesity, Carnivore, Keto
Obesity, or, Excessive corpulence : the various causes and the rational means of cure
Dr Dancel presented a paper in 1851 to the Academy of Sciences in Paris and said "For several years past I have given much consideration to the reduction of corpulency in cases where it interfered with the comforts of life, and I can reckon by thousands those who have followed my instructions. I have established it as a fact, without a single exception, that it is always possible to diminish obesity, by living chiefly upon meat, and partaking only of a small quantity of other kinds of food."
The principal constituents of fat, therefore, are carbon and hydrogen. Again, chemistry teaches that all food not consisting of flesh, such as vegetables, farinacea, sugars, &c., resemble fat, being chiefly composed of carbon and hydrogen; and, still more, that fat exists, already formed, in some vegetable substances, as oil of olives, oil of nuts, and oleaginous seeds. If, therefore, we introduce into the system substances rich in carbon and hydrogen, we must make fat as inevitably as the bee makes honey from its elements contained in the flowers.
On the other hand, we learn also from chemistry, that one of the principal constituents of meat is nitrogen, an element which does not enter into the composition of fat. Food consisting chiefly of meat must be less productive of fat than food mainly composed of carbon and hydrogen, such as vegetables, &c.
Distinguished chemists have endeavoured to shew in what manner the development of fat takes place in the animal economy. A paper was read by me before the Academy of Sciences, at Paris, on the 15th December, 1851, from which the following extract is made:
"Three different opinions are entertained by distinguished chemists, who have given attention to this subject. The first, that of Dumas, maintains that the fatty matter of the body is derived solely from substances analogous to fat in composition, which pre-exist in the food. The second opinion, that of Liebig, is to the effect that the formation of fat is due to a modification of those ternary compounds which constitute so large a proportion of the food of animals. The third opinion suggests that fat may arise in consequence of some special fermentation taking place in the stomach.
"Numerous experiments have been made, in order to determine which of these opinions is correct; but it may be safely said that no satisfactory conclusion has been arrived at.
"In the first place, the experiments have never been conducted under circumstances favourable to the formation of a correct opinion. It is obviously of the first importance, when conducting experiments of this nature, that the food should be supplied so as not to interfere with the tone of the general health, considered morally as well as physically. We can conceive that the deprivation of liberty, in the case of an animal usually in the enjoyment of freedom, may render the experiment of dubious import. Although man is omnivorous, it is impossible that any one can submit, for a great length of time, to live upon one kind of food only, without suffering a sense of loathing.
"What inference can be drawn from those experiments, made for the purpose of ascertaining whether sugar is capable of producing fat, when they were made upon pigeons and doves, which were fed solely upon this substance; at one time being deprived altogether of water, and at another time allowing them as much as they chose to drink?
"Chemists wished to know if butter could engender fat, and doves have been gorged with it, being deprived of all other food during the few days that the experiment lasted; at the end of which time they died, of course excessively lean; and the experimentalists thence concluded that butter does not produce fat. What an extraordinary idea, to feed a granivorous animal upon butter solely, in order to test the question referred to! This experiment forms the subject of a paper written by me, and inserted in the proceedings of the Academy of Sciences, for the year 1844.
"Other experiments upon animals, conducted likewise by men of science, are less open to criticism than the one just referred to; yet it must be confessed that no safe inference could be drawn from them. I am about to submit a few established facts, which may throw some light upon the question as to the cause of the development of fat.
"For several years past I have given much consideration to the reduction of corpulency in cases where it interfered with the comforts of life, and I can reckon by thousands those who have followed my instructions. I have established it as a fact, without a single exception, that it is always possible to diminish obesity, by living chiefly upon meat, and partaking only of a small quantity of other kinds of food. Make use of whatever medicine you please, it is impossible to obtain the same result in the case of a person partaking indiscriminately of everything which may be placed upon the table. There is yet another condition, without which success is impossible; that is, to absorb but little fluid, whether in the shape of soup or drink, or by means of the bath. A moist atmosphere is favourable to the development of fat: we increase in weight in wet weather.
"I have thousands of cases on record, in support of my statement. Persons from all parts of the world, who have followed my teachings, have experienced a decrease of their corpulence."
The paper upon this subject ended by saying, that according to my opinion, fat might be assimilated by either of the three several methods set forth in the beginning of the essay, one not forbidding the action of the others. I begged to be acknowledged by the Academy as the first who had established the fact that, in order to reduce corpulence without interfering with the general health, it is necessary to live chiefly upon meat, avoiding an excess of vegetable and aqueous food, or of any of which the basis is carbon or hydrogen.
Ancient History
Luxor, Luxor Governorate, Egypt
2475
B.C.E.
The Earliest Record of Sudden Death Possibly Due to Atherosclerotic Coronary Occlusion
WALTER L. BRUETSCH
The sudden death of an Egyptian noble man is portrayed in the relief of a tomb from the Sixth Dynasty (2625-2475 B.C.). Since there is indisputable evidence from the dissections of Egyptian mummies that atherosclerosis was prevalent in ancient Egypt, it was conjectured that the sudden death might have been due to atherosclerotic occlusion of the coronary arteries.
It may be presumptuous to assume that an Egyptian relief sculpture from the tomb of a noble of the Sixth Dynasty (2625-2475 B.C.) may suggest sudden death possibly due
to coronary atherosclerosis and occlusion. Much of the daily life of the ancient Egyptians has been disclosed to us through well-preserved tomb reliefs. In the same tomb that contains the scene of the dying noble, there is the more widely known relief "Netting Wildfowl in the Marshes." The latter sculpture reveals some of the devices used four thousand years ago for catching waterbirds alive. It gives a minute account of this occupation, which in ancient Egypt was both a sport and a means of livelihood for the professional hunter.
The relief (fig. 1), entitled "Sudden Death," by the Egyptologist von Bissing2 represents a nobleman collapsing in the presence of his servants. The revelant part of the explanatory text, as given by von Bissing, follows (translation by the author):
The interpretation of the details of the theme is left to the observer. We must attempt to comprehend the intentions of the ancient artist who sculptured this unusual scene. In the upper half (to the right) are two men with the customary brief apron, short hair covering the ears, busying themselves with a third man, who obviously has collapsed. One of them, bending over him, has grasped with both hands the left arm of the fallen man; the other servant, bent in his left knee, tries to uphold him by elevating the head and neck, using the knee as a support. Alas, all is in vain. The movement of the left hand of this figure, beat- ing against the forehead, seems to express the despair; and also in the tightly shut lips one can possibly recognize a distressed expression. The body of the fallen noble is limp. . . . Despite great restraint in the interpretation, the impression which the artist tried to convey is quite obvious. The grief and despair are also expressed by the figures to the left. The first has put his left hand to his forehead. (This gesture represents the Egyptian way of expressing sorrow.) At the same time he grasps with the other arm his companion who covers his face with both hands. The third, more impulsively, unites both hands over his head. ... The lord of the tomb, Sesi, whom we can identify here, has suddenly collapsed, causing consternation among his household.
In the section below (to the left) is shown the wife who, struck by terror, has fainted and sunk totheflor. Two women attendants are seen giving her first aid. To the right, one observes the wife, holding on to two distressed servants, leaving the scene. . . .
von Bissing mentions that the artist of the relief must have been a keen observer of real life. This ancient Egyptian scene is not unlike the tragedy that one encounters in present days, when someone drops dead of a "heart attack." The physician of today has almost no other choice than to certify the cause of such a death as due to coronary occlusion or thrombosis, unless the patient was known tohave been aflictedwith rheumatic heart disease or with any of the other more rare conditions which may result in sudden death.
Atherosclerosis among the Ancient Egyptians
The most frequent disease of the coronary arteries, causing sudden death, is atherosclerosis. What evidence is available that atherosclerosis was prevalent in ancient Egypt?
The first occasion to study his condition in peoples of ancient civilizations presented itself when the mummified body of Menephtah (approx.1280-1211B.C.), the reported "Pharaoh of the Hebrew Exodus" from Egypt was found. King Menephtah had severe atherosclerosis. The mummy was unwrapped by the archaeologist Dr. G. Elliot Smith, who sent a piece of the Pharaoh's aorta to Dr. S. G. Shattock of London (1908). Dr. Shattock was able to prepare satisfactory microscopic sections which revealed advanced aortic atherosclerosis with extensive depositions of calcium phosphate.
This marked the beginning of the important study of arteriosclerosis in Egyptian mummies by Sir Mare Armand Ruffer, of the Cairo Medical School(1910-11). His material included mummies ranging over a period of about 2,000 years (1580 B.C. - 525 A.D.).
The technic of embalming in the days of ancient Egypt consisted of the removal of all the viscera and of most of the muscles, destroying much of the arterial system. Often, however, a part or at times the whole aorta or one of the large peripheral arteries was left behind. The peroneal artery, owing to its deep situation, frequently escaped the em- balmer'sknife. Otherarteries,suchasthe femorals, brachials, and common carotids, had persisted.
In some mummies examined by Ruffer the abdominal aorta was calcified in its entirety, the extreme calcification extending into the iliae arteries. Calcified plaques were also found in some of the larger branches of the aorta. The common carotid arteries frequently revealed patches of atheroma, but the most marked atheroselerotic alterations were in the arteries of the lower extremities. The common iliae arteries were not infrequently studded with calcareous plaques and in some instances the femoral arteries were converted into rigid tubes. In other mummies, however, the same arteries were near normal.
What is known as Mdnekeberg's medial calcification was also observed in some of the mummified bodies. In a histologic section of a peronieal artery, the muscular coat had been changed almost wholly by calcification. In one of Ruffer's photographic plates, a part of a calcified ulnar artery is shown. The muscular fibers had been completely replaced by calcification.
In the aorta, as in present days, the atherosclerotic process had a predilection for the points of origin of the intercostal and other arteries. The characteristics and the localization of the arterial lesions observed in Egyptian mummies leaves litle doubt that atherosclerosis in ancient times was of the same nature and degree as seen in today's postmortem examinations.
As to the prevalence of the disease, Ruffer ventured to say that the Egyptians of ancient times suffered as much as modern man from arterial lesions, identical with those found in our times. Ruffer was well qualified to make this statement having performed many autopsies on modern Egyptians, Moslems, and other people of the Middle East. In going over his material and examining the accompanying photographic plates of arteries, one can have litle doubt that what Ruffer had observed in Egyptian mummies represented arteriosclerosis as it is known today.
Although the embalming left no opportunity to examine the coronary arteries inl mummified bodies, the condition of the aorta is a good index of the decree of atheroselerosis present elsewhere. In individuals with extensive atheroselerosis of the aorta, there is almost always a considerable degree of atherosclerosis in the coronary arteries. If Ruffer's statement is correct that the Egyptians of 3,000 years ago were afflicted with arteriosclerosis as much as we are nowadays, coronary occlusion must have been common among the elderly population of the pre-Christian civilizations.
Furthermore, gangrene of the lower extremities in the aged has been recognized since the earliest records of disease. Gangrene of the extremities for centuries did not undergo critical investigation until Cruveilhier (1791- 1873) showed that it was caused by atherosclerotic arteries, associated at times with a terminal thrombus.
SUMMARY
The record of a sudden death occurring in an Egyptian noble of the Sixth Dynasty (2625-2475 B.C.) is presented. Because of the prevalence of arteriosclerosis in ancient Egyptian mummies there is presumptive evidence that this incident might represent sudden death due to atheroselerotic occlusion of the coronary arteries.
Cairo, Cairo Governorate, Egypt
945
B.C.E.
Cardiology in Ancient Egypt by Eugene V. Boisaubin, MD
Egyptians describe coronary ischemia: "if thou examinest a man for illness in his cardia and he has pains in his arms, and in his breast and in one side of his cardio... it is death threatening him."
The classic pattern of cardiac pain--radiation to the left arm--was so well known that the ancient Egyptians and Copts even identified the left ring finger as the "heart" finger.
Altogether, ancient Egyptians were aware of a variety of abnormal cardiac conditions, particularly of angina pectoris and sudden death, arrhythmia, aneurysm, congestive heart failure, and venous insufficiency. Numerous remedies for afflicitions of the heart are found throughout the Ebers payrus.
There were a range of them using different foods, some even including carbohydrates like dates or honey and dough, but interesting, there is another combination of "fat flesh, incense, garlic, and writing fluid".
Extensive histologic analysis of mummies began, however; well before the development of the scanning electron microscope. In 1912, Shattock' made sections of the calcified aorta of Pharaoh Merneptah; and the work of Sir Marc Armand Rufer, published posthumously in 1921, is our most valuable early source of information about vascular disease in ancient Egyptians. Ruffer was able to study a relatively large number of tissue specimens from mummies, mainly from New Kingdom (1600-1100 BC) burials, but covering a wide period of time. In a mummy of the 28th to 30th Dynasty (404-343 BC), he observed atheromas in the common carotids and calcific atheromas in the left subclavian, common iliac, and more peripheral arteries. Ruffer concluded from the state of the costal cartilage that this mummy was not that of an old person. A mummy of a man of the Greek period (ca. 300 to 30 BC), who died at not over 50 years of age, showed atheromas of the aorta and brachial arteries. Since the discoveries of Rufer, numerous other mummies, whose ages at death ranged from the 4th to the 8th decade, have shown similar vascular changes (Fig.4).
In 1931, Long described a female mummy of the 21st Dynasty (1070-945 BC), found at Deir-el- Bahari-that of the lady Teye, who died at about 50 years of age. The heart showed calcification of one mitral cusp, and thickening and calcification of the coronary arteries. The myocardium is said to have had patchy fibrosis, and the aorta "nodular arteriosclerosis." The renal capsule was thickened, many of the glomeruli were fibrosed, and the medium-sized renal vessels were sclerotic. The condition appears to be that of hypertensive arteriosclerotic disease associated with atheromatous change. In the 1960s, Sandison examined and photographed mummy arteries using modern histologic methods (Fig.5). Arteries in the mummy tissues were described as tape-like, but could be dissected easily, whereupon arteriosclerosis, atheroma with lipid depositions, reduplication of the internal elastic lamina, and medial calcification were readily visible under microscopy.
Still more recently, one of the most extensively studied Egyptian mummies has been PUMIL from the Pennsylvania University Museum(hence its initials), now on loan to the National Museum of Natural History at the Smithsonian. It is believed to be from the later Ptolemaic period, circa 170BC. The heart and portions of an atherosclerotic aorta were found in the abdominal cavity. Histologically, large and small arterioles and arteries from other organs showed areas of intimal fibrous thickening typical of sclerosis. These findings are particularly striking since the estimated age of PUM I at time of death was between 35 and 40 years.
