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Obesity

Obesity

Recent History

July 2, 1853

Jean-Francois Dancel

Obesity, Carnivore, Keto

Obesity, or, Excessive corpulence: the various causes and the rational means of cure

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Madame L of Amiens, France uses Dancel's meat-diet for obesity.

In the month of June, 1853, Madame de L., of Amiens, consulted me on her own behalf, and also on that of her husband—both labouring under obesity. I gave her the necessary directions, together with medicine sufficient to last two months. She wrote to me on the 2nd of July in the following terms:


"Sir,—In fulfilment of my promise, I send you a statement of the result of your treatment. My husband has lost eleven pounds in weight, and enjoys excellent health. As for myself, owing to severe indisposition after my return home from Paris, I have only adopted your treatment during the last eight days. Please inform me whether the medicine you furnished to me a month ago is too old to be of any service.

"I have the honour, &c.,
"F. L."

I answered this letter, and no doubt the lady has derived as much benefit as her husband from the treatment.

August 15, 1853

Jean-Francois Dancel

Obesity, Carnivore, Keto

Obesity, or, Excessive corpulence : the various causes and the rational means of cure

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One would scarcely believe that a lady, reduced to despair on account of her obesity, and threatening to commit suicide unless relieved of her embonpoint, could promise that she would obey my instructions to live chiefly upon a meat diet, and to abstain from inordinate quantities of fluid, yet the very next day would resume her customary mode of living;—breakfasting upon eggs, preserves, and two or three cups of sweetened tea; and dine upon rich pastry and sweetmeats, accompanied with a full allowance of champagne. I could not have believed it possible had I not witnessed it myself.

It is said, that in order to be understood and believed, it is necessary to repeat the same thing over and over again. But all things must have an end; and all the cases which I might yet report, would still end in diminution of obesity. It may be said, however, that, like most medical writers, I report only favourable cases, and conceal those which are unfavourable. My answer is, that I have never treated a single case in which a favourable result has not been obtained, provided the patient has observed my directions for even eight days; and I am satisfied that if any one could be found to say that he has not been benefited, that it would be because he has not been willing to carry out the treatment for even eight days. It has no doubt frequently happened that a patient has consulted me, and has then followed my directions for two, three, or even four days, and then, for some cause, has given them up: under these circumstances it might be said that no benefit has been derived.


Many such cases have occurred. In one instance, a wealthy man, a gold-beater by trade, living in Paris, sought my advice. He followed my system for several weeks, without success. One day I said to him, "I can only explain your want of success by attributing it to excessive drinking. You live upon meat principally, it is true; but how much liquid do you imbibe daily?" His answer was,—"I cannot abstain from drinking when thirsty, and my thirst is frequent. I spend the whole day in the factory, among fifteen or twenty workmen, and the heat is necessarily great, as the nature of our manufacture demands it, and I am therefore obliged to drink a great deal." I consequently recommended him to abstain from further trial of a system which, under these circumstances, could not possibly be of any benefit.


We meet with people who make, or seem to make, a resolution to live according to a certain plan, for eight or ten days, and who, like spoiled children, forget the very next day the resolution they had made. I have met with many such cases. One would scarcely believe that a lady, reduced to despair on account of her obesity, and threatening to commit suicide unless relieved of her embonpoint, could promise that she would obey my instructions to live chiefly upon a meat diet, and to abstain from inordinate quantities of fluid, yet the very next day would resume her customary mode of living;—breakfasting upon eggs, preserves, and two or three cups of sweetened tea; and dine upon rich pastry and sweetmeats, accompanied with a full allowance of champagne. I could not have believed it possible had I not witnessed it myself.

Men generally carry out my directions more faithfully than women, being firmer and more persevering in their resolves.

I am almost angry at times with this want of perseverance in persons who boast that they have carried out my treatment without success. It would be an easy matter to shew that the want of success in such cases is entirely their own fault.

A young lady of one of the most illustrious families of France, and married to a wealthy foreign nobleman, consulted me in the month of May, 1853, in reference to her corpulence. She told me that her cousin, the Duchess of X., had derived great benefit from my treatment; and from what she had witnessed in her case, she was induced to place herself under my care. She promised to commence my system on the following day.

A few days afterwards I saw her. She told me she had forgotten to take her medicine the day before. In subsequent visits, she confessed that she had not taken any medicine, either because she had been up very late the previous evening and had laid in bed late that morning, or that she had been spending a day or two in the country; or that, having been out for an early ride, she had forgotten all about it. On the occasion of my last visit, she told me that she was going for some time to her country-seat, and from thence intended to visit a watering-place. The Baroness did not follow my treatment for three days consecutively, and consequently lost nothing of her embonpoint. Under such circumstances, want of success ought surely not to be attributed to inefficacy of the treatment.

A very corpulent professor adopted my system for eight days, and lost three pounds and a half in weight. Being relieved at the same time from a sense of oppression which had continually troubled him, he was delighted, and spoke of the happy results to many of his acquaintances. Unfortunately at this time he received from the country a present of a large basket of grapes, and being very partial to them, neglected my instructions, and partook of them inordinately as long as they lasted. The consequence is, that the professor is as fat as ever, although he had followed my plan of treatment for eight days. Now whose fault is this? Nevertheless, his acquaintances, to whom he had spoken of being under my care, will attribute the failure to me. I shall see him again, no doubt, some of these days, when in danger of suffocation.

The reader who has perused the preceding cases of cure, may say that I have omitted to speak of obesity accompanied with skin disease, and in my introduction mention has been made of its frequency. In truth, many such cases have been met with; but skin disease, in my opinion, is of such a nature that it is better not to give a hint even of the parties in whom it has been met with and cured at the same time with co-existing corpulence.

My method of reducing obesity being thus frankly explained, is perhaps likely to lose its value in the eyes of many, owing to its extreme simplicity. M. Desbouillons, of Brest, a patient whom I successfully treated, wrote to me on the 15th August, 1853:—"On reading your treatise a second time, I cannot but express my astonishment that the medical faculty should so long have failed to discover the means which you now so successfully employ for the cure of obesity."

Having accomplished the object I had in view, it matters not whether it be the result of little study or of long and deep enquiry into the secrets of animated nature; my satisfaction consists in having destroyed those false and prejudicial doctrines which had existed for ages in the writings and teachings of philosophers, and in having demonstrated a truth destined to render important services to our common humanity.

October 19, 1853

Jean-Francois Dancel

Obesity, Carnivore, Keto

Obesity, or, Excessive corpulence: the various causes and the rational means of cure

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A landlord at the Golden Lion Hotel loses 90 pounds going from 270 to 160, and tells many about Dancel's meat-cure. He wrote in a letter: "Immediately after adopting your system, my fat began to disappear, my appetite improved, and, after a few months, my weight was reduced to one hundred and sixty pounds, and my circumference to thirty-two inches. My health is now excellent."

Towards the latter end of 1851, Madame Wimy, from the town of Marle, came to consult me in reference to her husband, who was labouring under obesity to such a degree as to be unable to attend to his business. I gave her the necessary advice, together with some medicine. On the 19th of December Madame Wimy told me by letter that her husband had already much improved, that his breathing was easier, he was more capable of exertion, and that his corpulence had notably diminished. This lady again wrote to me in the following year, requesting a further supply of medicine. She said:—"My husband, before commencing your treatment, weighed two hundred and seventy pounds: he now weighs only two hundred, and hopes to weigh still less. You are no doubt in the frequent receipt of letters seeking advice, for we have many inquiries for your address."

In truth the case of M. Wimy has brought me a great many patients. Anxious to know whether he still continued my plan of treatment, and wishing to introduce a statement of his case in this the third edition of my work, I wrote to M. Wimy on the 16th of October last and received the following reply:


"Marle, 19th Oct., 1853.

"Sir,—In your letter of the 16th, you requested me to give a somewhat detailed statement of my case. I commenced the treatment under your directions, the latter part of 1851, and continued it during the early part of 1852. My weight was two hundred and seventy pounds, and I measured sixty-one inches in circumference. I walked with great difficulty—suffered much pain in the kidneys—my legs were swollen. I had a constant cough, and was much troubled with drowsiness. Immediately after adopting your system, my fat began to disappear, my appetite improved, and, after a few months, my weight was reduced to one hundred and sixty pounds, and my circumference to thirty-two inches. My health is now excellent. Being landlord of the Golden Lion Hotel, at Marle, where the stages put up, my recovery is known to a great many; and travellers who stopped at my house two years ago, when I was labouring under obesity, on seeing me at present, and noticing the wonderful change which has taken place, invariably ask by what means it has been effected.


"It always affords me great pleasure to acknowledge that my cure is due to your system of treatment.

"I have the honour to be, &c.,
"Jules Wimy.

"Golden Lion Hotel,
Marle, Aisne."


A person who visited Marle about four months ago, and who had not seen M. Wimy since the great change had been effected in his appearance, was much astonished, and made inquiries respecting the cure. Some time afterwards, this person met, at Orleans, a wealthy gentleman, about forty years of age, suffering from obesity, and told him what he had witnessed at Marle; recommending him at the same time to visit Paris, in order that he might have the advice of the doctor who had freed Wimy from his excessive fat. This gentleman wrote to Marle, before coming to Paris, and received a satisfactory answer.


He called to consult with me, saying that he wished to place himself under my care, provided that it would not interfere with his business or with his usual habits. He is postmaster at Orleans, and, previous to the building of the railroad, had a great deal of business to attend to. Having many more horses than necessary for his business at Orleans, he has opened a livery stable in Paris. He is consequently obliged to attend all the fairs and markets, in order to purchase horses and provender for his two establishments,—the one at Paris and the other at Orleans, and is almost constantly travelling between these two cities, and therefore leads a life of great activity. He weighs two hundred and twenty-two pounds, and wishes to lose fifty pounds of fat, but he cannot afford to lose a day from his business.


My reply to Mr. M. was, that so far from my treatment demanding any cessation from work, it would rather give him strength to carry it on. He began the treatment ten weeks since, and has already lost between twenty-eight and thirty pounds of fat; and, as I had promised, without causing him the loss of a single day.

January 5, 1869

Jean-Francois Dancel

Obesity, Carnivore, Keto

The Practice of Medicine - Obesity - Thomas Hawkes Tanner

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"The instance of the slaves in Italy, who got fat during the grape and fig season, has been quoted by Galen. In sugar-growing countries the negroes and cattle employed on the plantations grow remarkably stout while the cane is being gathered and the sugar extracted."

The causes of obesity are numerous. It is often hereditary or constitutional, the inclination being derived from either parent. This tendency is seen not only in individuals but in nations: e.g., the Dutch are as stout, as the Americans are proverbially thin. Over-feeding will induce fat, and so will the habit of taking too much fluid. The obese are not always great eaters: but they invariably drink a great deal, even though it be only water. Farinaceous and vegetable foods are fattening, and saccharine matters are especially so. The instance of the slaves in Italy, who got fat during the grape and fig season, has been quoted by Galen. In sugar-growing countries the negroes and cattle employed on the plantations grow remarkably stout while the cane is being gathered and the sugar extracted. During this harvest the saccharine juices are freely consumed; but when the season is over, the superabundant adipose tissue is gradually lost. And then amongst other causes we must reckon insufficient exercise, long continued pros perity and ease of mind, indulgence in too much sleep, and an absence of the sexual appetite. Eunuchs are generally described as being flabby and fat; whilst amongst the lower animals, fattening is readily produced after the removal of the testicles or ovaries. The way in which the same fact can be made to tell in favour of two opposing theories is curiously illustrated by two writers on this subject. Thus, Wadd cites the butchers as examples of corpulence, alleging that their excellent condition is due to animal food. He speaks particularly of the advantages of the “butcher's steak; " and does not believe that these men and their wives owe their good looks to “the effluvia of the meat."* Dancel also speaks of the frequency with which the members of the same class become obese; but he says it is because the butchers eat meat and plenty of vegetables, while their wives generally prefer vegetables to animal food. He has no faith in the opinion that their embonpoint has some connection with the atmosphere of nutritive animal odours in which they live. 


Fats are obtained abundantly from both the animal and vegetable kingdoms. Their predominating elements are carbon and hydrogen. They never contain nitrogen, except as an accidental ingredient. They are made up of three closely allied bodies; viz., stearin (from otéap = suet ], margarin ( from its lustrous appearance, pápyapov = a pearl ], and olein [ oleum = oil ] which is Huid. When fatty matters are heated with the hydrated alkalies, they undergo saponification, during which process a viscid sweet fluid glycerine ( dukùç = sweet ] -is yielded. Now several physiological studies lead to the conclusion that oils and fats may not only be formed in the system from food which contains it ready prepared, but also from the chemical transformation of starch or sugar. Many experiments have been performed on geese, ducks, and pigs, which have proved that these animals accumulate much more fat than could be accounted for by that present in the food. M. Flourens had the bears at the Jardin des Plantes fed exclusively on bread, and they became excessively fat. Magendie, in making experiments on the forage of horses, found that these animals constantly returned more fat in their excrements than their food contained. And several authors have shown that bees form wax, which strictly belongs to the group of fats, when fed exclusively on purified sugar. If with foods of this nature the animals be subjected to a warm atmosphere and allowed but little room for movement, the adipose tissue rapidly gets increased. At Strasburg, the place of all others most noted for its pâtés de foie gras, the geese are fatted by shutting them up in coops within a room heated to a very high temperature, and stuffing them constantly with food. Here all the conditions for insuring obesity are resorted to --- viz. external heat, obscurity, inactivity, and the cramming of the animals with nourishment.

January 1, 1882

Obesity (Corpulence) and its treatment according to physiological principles

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the German physiologist Wilhelm Ebstein cites Cantani as an authority for the use of pure fat in diabetic diets. “up to about 200 grams of fat is well tolerated by the majority of diabetics”

Cantani’s dietary regime involved periods of energy restriction, however the German physiologist Wilhelm Ebstein cites Cantani as an authority for the use of pure fat in diabetic diets. In 1892 Ebstein published his comprehensive review of the literature on diet, lifestyle, and diabetes, Über die Lebensweise der Zuckerkranken, which includes the statement that “up to about 200 grams of fat is well tolerated by the majority of diabetics” [7]. Also in 1892, Ebstein’s book on Corpulence and its Treatment on Physiological Principles, which contained brief summaries of his findings on fat and diabetes, was translated into English [8]. In this book and his subsequent work On the Regimen to be Adopted in Cases of Gout Ebstein discussed experimental evidence on the metabolism of protein and the desirability of limiting both protein and carbohydrate, and increasing fat, in the treatment of metabolic diseases [9].


German Txt (Very hard to read)

https://archive.org/stream/diefettleibigkei00ebst/diefettleibigkei00ebst_djvu.txt


English Translation Scanned PDF:

https://dlcs.io/pdf/wellcome/pdf-item/b21050533/0


Ebstein describes Rabbit Starvation:

Page 37:

Notwithstanding the vastly important part played by nitrogenous food in human dietetics, those substances that contain no nutritive ingredients except albumen, as for instance flesh destitute of fat, are not proper food for man. As flesh satisfies his demand for carbon only when it is consumed four times in excess of the quantity required to yield the nitrogen needed for his nourishment, such a course would in the first place be far from economical, seeing that meat is one of the dearest articles of food. And then we should very soon find it impossible to consume every day the 90 oz. of pure flesh required for this purpose.

The dietetic systems of treatment now in vogue are based on an almost exclusively albuminous diet. In 1850 Chambers had already pronounced in favour of this regimen, his system excluding all fat substances such as fat, oil, butter, milk, cream, as well as sugar. Of starch-flour in the form of potatoes and even of bread he remarked, that they should be looked on with the greatest suspicion. He also insisted on a diminished consumption of liquids. 

We thus perceive that strictly speaking Chambers' cure differs in no respect from that, by which Banting grew lean in the hands of his physician Harvey, and which has received the name of the Banting cure from the patient, who has written an account of his malady and curative process. From it's specially operative factor Kisch has named it the "Anti-Fat Cure".


Cantani has gone still more vigourously to work. He bars not only all fats - fat meat, fat fish, cheese (owing to its sebacic acid), but all farinaceous preparations, all saccharine foods, sweet and aromatic fruits. Only when the patient is unable to continue this diet long enough, either through excessive repugnance to meat, or nausea of the stomach, or muscular debility, he combines it with the Harvey-Banting system, which also no doubt anathematises the fats, but allows a certain quantity of carbohydrates. 

    Hence these cures have this in common that both alike to the very utmost exclude fats, which they regard as the chief source of the accumulation of fat in the body.

    Now I will by no means deny that a series of cures does result from the Harvey-Banting and Cantani methods, that is to say, by these means corpulent persons become thin. But on the other hand it must be allowed that: 


Page 44:

Ebstein strongly supports fat for satiety.


"I would now specially insist that the suitable quantity of alimentary fat must not forsooth remove hunger in such a way as to produce dyspeptic symptoms or injure the digestion; and this I dwell upon because the question has already been more than once placed before me by competent colleagues. It is of course a tacit assumption that the fat like all other human aliments, be of unexceptionable quality. The experiments made on persons suffering from fistula in the stomach, have already shown that fat substances disturb the digestion only when they are consumed too abundantly, and I have myself often enough administered with surprising succcess alimentary fat to dyspeptics of the worst type, while limitng their allowance of carbohydrates. But my own numerous experiences have also convinced me, that in the treatment of corpulency fat agrees perfectly well even with those, who had previously regarded it with nausea. I have even noticed a total disappearance of the dyspeptic affections, which the corpulent had hitherto brought upon themselves by an improper diet. The patients preserve a good appetite, which they must learn to moderate by yielding only the actual feeling of hunger. 


The reason of this alleviation of the feeling of hunger with a proper allowance of fat in the diet is due to the circumstance, that fat checks the decomposition of albumen, and that consequently the craving to make good the waste makes itself felt more slowly and less urgently. Precisely because fewer albuminates have been decomposed, fewer require to be replaced. As by the addition of fat to the diet in the same proportion as the decomposition of albumen is diminished, the quantity of nitrogenous refuse from the assimilated substances is also limined, a smaller amount of drink is needed for its removal. Hence in this way thirst as well as hunger becomes appeased. That fats reduce the craving for food was already known to Hippocrates, who remarks in the section dealing with those that wish to become fat or lean: "the dishes must be succelent, for in this way we are easiest sated." Very interesting to me was a communication from Loew, bearing on the point that the use of fat is also effective in checking the craving for liquids. After the consumption of fat in hot climates he always noticed a diminished demand for water; thirst became decidely less irksome.


This property of fat to produce satiety more rapidly, to diminish the craving for food and abate the feeling of thirst, facilitates to an extraordinary degree the introduction of the modified diet. For to the sacrifices which after all must in any case be required of the corpulent, nothing further need be superadded at least in this direction. On the contrary, the permission to enjoy certain succulent things, always of course in moderation, as for instance salmon, pate de foie gras and such like delicacies, reconciles the corpulent gourmet to his sacrifices. These consist in the exclusion of the carbohydrates. Sugar, sweets of all kinds, potatoes in every form I forbid unconditionally. The quantity of bread is limited at most to from 3 to 3.5 oz a day, and of vegetables I allow asparagus, spinach, the various kinds of cabbage and especially the leguminous, whose value as conveyors of albumen, as Voit rightly observes, is known to few. Of meats I exclude none, and the fat in the flesh I do not wish to be avoided, but on the contrary sought after. I permit bacon fat, fat roast pork and mutton, kidney fat, and when no other fat is at hand I recommend marrow to be added to soups. I allow the sauces as well as the vegetables to be made juicy, as did Hippocrates, only for his sesam-oil I substitute butter. 


In spite of all this it would be little to the point to say that I treat the corpulent with fat, whereas I simply vindicate the full claims to which fat is entitled as an article of food. I do not suppose that the corpulent, with who we are practically concerned, will have to consume anything like the quantity of fat that Voit concedes to the working man, or that is allowed to the rank and file of the German imperial army in time of war, say from 7 to 9 oz. daily. I reduce this daily allowance of fat to from 2 to 3.5 oz on an average. The quantity of course changes with the individual relations, nor is it the same for every day. Under the influence of this diet it becomes possible to do with a less quantity of meat. This again I reduce to fully one half or three-fifths of the quantity required in the Banting system, which varies from 13 to 16 oz. a day.



Ancient History

Luxor, Luxor Governorate, Egypt

2475

B.C.E.

The Earliest Record of Sudden Death Possibly Due to Atherosclerotic Coronary Occlusion
WALTER L. BRUETSCH

The sudden death of an Egyptian noble man is portrayed in the relief of a tomb from the Sixth Dynasty (2625-2475 B.C.). Since there is indisputable evidence from the dissections of Egyptian mummies that atherosclerosis was prevalent in ancient Egypt, it was conjectured that the sudden death might have been due to atherosclerotic occlusion of the coronary arteries.

It may be presumptuous to assume that an Egyptian relief sculpture from the tomb of a noble of the Sixth Dynasty (2625-2475 B.C.) may suggest sudden death possibly due

to coronary atherosclerosis and occlusion. Much of the daily life of the ancient Egyptians has been disclosed to us through well-preserved tomb reliefs. In the same tomb that contains the scene of the dying noble, there is the more widely known relief "Netting Wildfowl in the Marshes." The latter sculpture reveals some of the devices used four thousand years ago for catching waterbirds alive. It gives a minute account of this occupation, which in ancient Egypt was both a sport and a means of livelihood for the professional hunter.

The relief (fig. 1), entitled "Sudden Death," by the Egyptologist von Bissing2 represents a nobleman collapsing in the presence of his servants. The revelant part of the explanatory text, as given by von Bissing, follows (translation by the author):


The interpretation of the details of the theme is left to the observer. We must attempt to comprehend the intentions of the ancient artist who sculptured this unusual scene. In the upper half (to the right) are two men with the customary brief apron, short hair covering the ears, busying themselves with a third man, who obviously has collapsed. One of them, bending over him, has grasped with both hands the left arm of the fallen man; the other servant, bent in his left knee, tries to uphold him by elevating the head and neck, using the knee as a support. Alas, all is in vain. The movement of the left hand of this figure, beat- ing against the forehead, seems to express the despair; and also in the tightly shut lips one can possibly recognize a distressed expression. The body of the fallen noble is limp. . . . Despite great restraint in the interpretation, the impression which the artist tried to convey is quite obvious. The grief and despair are also expressed by the figures to the left. The first has put his left hand to his forehead. (This gesture represents the Egyptian way of expressing sorrow.) At the same time he grasps with the other arm his companion who covers his face with both hands. The third, more impulsively, unites both hands over his head. ... The lord of the tomb, Sesi, whom we can identify here, has suddenly collapsed, causing consternation among his household.

In the section below (to the left) is shown the wife who, struck by terror, has fainted and sunk totheflor. Two women attendants are seen giving her first aid. To the right, one observes the wife, holding on to two distressed servants, leaving the scene. . . .

von Bissing mentions that the artist of the relief must have been a keen observer of real life. This ancient Egyptian scene is not unlike the tragedy that one encounters in present days, when someone drops dead of a "heart attack." The physician of today has almost no other choice than to certify the cause of such a death as due to coronary occlusion or thrombosis, unless the patient was known tohave been aflictedwith rheumatic heart disease or with any of the other more rare conditions which may result in sudden death.


Atherosclerosis among the Ancient Egyptians 


The most frequent disease of the coronary arteries, causing sudden death, is atherosclerosis. What evidence is available that atherosclerosis was prevalent in ancient Egypt?

The first occasion to study his condition in peoples of ancient civilizations presented itself when the mummified body of Menephtah (approx.1280-1211B.C.), the reported "Pharaoh of the Hebrew Exodus" from Egypt was found. King Menephtah had severe atherosclerosis. The mummy was unwrapped by the archaeologist Dr. G. Elliot Smith, who sent a piece of the Pharaoh's aorta to Dr. S. G. Shattock of London (1908). Dr. Shattock was able to prepare satisfactory microscopic sections which revealed advanced aortic atherosclerosis with extensive depositions of calcium phosphate.

This marked the beginning of the important study of arteriosclerosis in Egyptian mummies by Sir Mare Armand Ruffer, of the Cairo Medical School(1910-11). His material included mummies ranging over a period of about 2,000 years (1580 B.C. - 525 A.D.).

The technic of embalming in the days of ancient Egypt consisted of the removal of all the viscera and of most of the muscles, destroying much of the arterial system. Often, however, a part or at times the whole aorta or one of the large peripheral arteries was left behind. The peroneal artery, owing to its deep situation, frequently escaped the em- balmer'sknife. Otherarteries,suchasthe femorals, brachials, and common carotids, had persisted.

In some mummies examined by Ruffer the abdominal aorta was calcified in its entirety, the extreme calcification extending into the iliae arteries. Calcified plaques were also found in some of the larger branches of the aorta. The common carotid arteries frequently revealed patches of atheroma, but the most marked atheroselerotic alterations were in the arteries of the lower extremities. The common iliae arteries were not infrequently studded with calcareous plaques and in some instances the femoral arteries were converted into rigid tubes. In other mummies, however, the same arteries were near normal.


What is known as Mdnekeberg's medial calcification was also observed in some of the mummified bodies. In a histologic section of a peronieal artery, the muscular coat had been changed almost wholly by calcification. In one of Ruffer's photographic plates, a part of a calcified ulnar artery is shown. The muscular fibers had been completely replaced by calcification.


In the aorta, as in present days, the atherosclerotic process had a predilection for the points of origin of the intercostal and other arteries. The characteristics and the localization of the arterial lesions observed in Egyptian mummies leaves litle doubt that atherosclerosis in ancient times was of the same nature and degree as seen in today's postmortem examinations.


As to the prevalence of the disease, Ruffer ventured to say that the Egyptians of ancient times suffered as much as modern man from arterial lesions, identical with those found in our times. Ruffer was well qualified to make this statement having performed many autopsies on modern Egyptians, Moslems, and other people of the Middle East. In going over his material and examining the accompanying photographic plates of arteries, one can have litle doubt that what Ruffer had observed in Egyptian mummies represented arteriosclerosis as it is known today.


Although the embalming left no opportunity to examine the coronary arteries inl mummified bodies, the condition of the aorta is a good index of the decree of atheroselerosis present elsewhere. In individuals with extensive atheroselerosis of the aorta, there is almost always a considerable degree of atherosclerosis in the coronary arteries. If Ruffer's statement is correct that the Egyptians of 3,000 years ago were afflicted with arteriosclerosis as much as we are nowadays, coronary occlusion must have been common among the elderly population of the pre-Christian civilizations.


Furthermore, gangrene of the lower extremities in the aged has been recognized since the earliest records of disease. Gangrene of the extremities for centuries did not undergo critical investigation until Cruveilhier (1791- 1873) showed that it was caused by atherosclerotic arteries, associated at times with a terminal thrombus.


SUMMARY

The record of a sudden death occurring in an Egyptian noble of the Sixth Dynasty (2625-2475 B.C.) is presented. Because of the prevalence of arteriosclerosis in ancient Egyptian mummies there is presumptive evidence that this incident might represent sudden death due to atheroselerotic occlusion of the coronary arteries.

Cairo, Cairo Governorate, Egypt

945

B.C.E.

Cardiology in Ancient Egypt by Eugene V. Boisaubin, MD

Egyptians describe coronary ischemia: "if thou examinest a man for illness in his cardia and he has pains in his arms, and in his breast and in one side of his cardio... it is death threatening him."

The classic pattern of cardiac pain--radiation to the left arm--was so well known that the ancient Egyptians and Copts even identified the left ring finger as the "heart" finger.


Altogether, ancient Egyptians were aware of a variety of abnormal cardiac conditions, particularly of angina pectoris and sudden death, arrhythmia, aneurysm, congestive heart failure, and venous insufficiency. Numerous remedies for afflicitions of the heart are found throughout the Ebers payrus. 

There were a range of them using different foods, some even including carbohydrates like dates or honey and dough, but interesting, there is another combination of "fat flesh, incense, garlic, and writing fluid".


Extensive histologic analysis of mummies began, however; well before the development of the scanning electron microscope. In 1912, Shattock' made sections of the calcified aorta of Pharaoh Merneptah; and the work of Sir Marc Armand Rufer, published posthumously in 1921, is our most valuable early source of information about vascular disease in ancient Egyptians. Ruffer was able to study a relatively large number of tissue specimens from mummies, mainly from New Kingdom (1600-1100 BC) burials, but covering a wide period of time. In a mummy of the 28th to 30th Dynasty (404-343 BC), he observed atheromas in the common carotids and calcific atheromas in the left subclavian, common iliac, and more peripheral arteries. Ruffer concluded from the state of the costal cartilage that this mummy was not that of an old person. A mummy of a man of the Greek period (ca. 300 to 30 BC), who died at not over 50 years of age, showed atheromas of the aorta and brachial arteries. Since the discoveries of Rufer, numerous other mummies, whose ages at death ranged from the 4th to the 8th decade, have shown similar vascular changes (Fig.4).


In 1931, Long described a female mummy of the 21st Dynasty (1070-945 BC), found at Deir-el- Bahari-that of the lady Teye, who died at about 50 years of age. The heart showed calcification of one mitral cusp, and thickening and calcification of the coronary arteries. The myocardium is said to have had patchy fibrosis, and the aorta "nodular arteriosclerosis." The renal capsule was thickened, many of the glomeruli were fibrosed, and the medium-sized renal vessels were sclerotic. The condition appears to be that of hypertensive arteriosclerotic disease associated with atheromatous change. In the 1960s, Sandison examined and photographed mummy arteries using modern histologic methods (Fig.5). Arteries in the mummy tissues were described as tape-like, but could be dissected easily, whereupon arteriosclerosis, atheroma with lipid depositions, reduplication of the internal elastic lamina, and medial calcification were readily visible under microscopy.


Still more recently, one of the most extensively studied Egyptian mummies has been PUMIL from the Pennsylvania University Museum(hence its initials), now on loan to the National Museum of Natural History at the Smithsonian. It is believed to be from the later Ptolemaic period, circa 170BC. The heart and portions of an atherosclerotic aorta were found in the abdominal cavity. Histologically, large and small arterioles and arteries from other organs showed areas of intimal fibrous thickening typical of sclerosis. These findings are particularly striking since the estimated age of PUM I at time of death was between 35 and 40 years.

Books

UNHOLY TRINITY: How Carbs, Sugar & Oils Make Us Fat, Sick & Addicted and How to Escape Their Grip

Published:

September 25, 2023

UNHOLY TRINITY: How Carbs, Sugar & Oils Make Us Fat, Sick & Addicted and How to Escape Their Grip

Rethinking Diabetes: What Science Reveals About Diet, Insulin, and Successful Treatments

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January 2, 2024

Rethinking Diabetes: What Science Reveals About Diet, Insulin, and Successful Treatments
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